RT Journal Article
SR Electronic
T1 Learning alters neural activity to simultaneously support memory and action
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.07.05.498856
DO 10.1101/2022.07.05.498856
A1 Darby M. Losey
A1 Jay A. Hennig
A1 Emily R. Oby
A1 Matthew D. Golub
A1 Patrick T. Sadtler
A1 Kristin M. Quick
A1 Stephen I. Ryu
A1 Elizabeth C. Tyler-Kabara
A1 Aaron P. Batista
A1 Byron M. Yu
A1 Steven M. Chase
YR 2022
UL http://biorxiv.org/content/early/2022/07/06/2022.07.05.498856.abstract
AB How are we able to learn new behaviors without disrupting previously learned ones? To understand how the brain achieves this, we used a brain-computer interface (BCI) learning paradigm, which enables us to detect the presence of a memory of one behavior while performing another. We found that learning to use a new BCI map altered the neural activity that monkeys produced when they returned to using a familiar BCI map, in a way that was specific to the learning experience. That is, learning left a “memory trace.” This memory trace co-existed with proficient performance under the familiar map, primarily by altering dimensions of neural activity that did not impact behavior. Such a memory trace could provide the neural underpinning for the joint learning of multiple motor behaviors without interference.Competing Interest StatementThe authors have declared no competing interest.