PT  - JOURNAL ARTICLE
AU  - Wei Wang
AU  - Sabrina Lusvarghi
AU  - Rahul Subramanian
AU  - Nusrat J. Epsi
AU  - Richard Wang
AU  - Emilie Goguet
AU  - Anthony C Fries
AU  - Fernando Echegaray
AU  - Russell Vassell
AU  - Si’Ana Coggins
AU  - Stephanie A. Richard
AU  - David A. Lindholm
AU  - Katrin Mende
AU  - Evan Ewers
AU  - Derek Larson
AU  - Rhonda E. Colombo
AU  - Christopher Colombo
AU  - Janet O. Joseph
AU  - Julia Rozman
AU  - Alfred Smith
AU  - Tahaniyat Lalani
AU  - Catherine Berjohn
AU  - Ryan Maves
AU  - Milissa Jones
AU  - Rupal Mody
AU  - Nikhil Huprikar
AU  - Jeffrey Livezey
AU  - David Saunders
AU  - Monique Hollis-Perry
AU  - Gregory Wang
AU  - Anuradha Ganesan
AU  - Mark P. Simons
AU  - Christopher C. Broder
AU  - David Tribble
AU  - Eric D. Laing
AU  - Brian Agan
AU  - Timothy H. Burgess
AU  - Edward Mitre
AU  - Simon D. Pollett
AU  - Leah C. Katzelnick
AU  - Carol D. Weiss
TI  - Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection
AID  - 10.1101/2022.07.05.498883
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.07.05.498883
4099  - http://biorxiv.org/content/early/2022/07/06/2022.07.05.498883.short
4100  - http://biorxiv.org/content/early/2022/07/06/2022.07.05.498883.full
AB  - The rapid emergence of new SARS-CoV-2 variants challenges vaccination strategies. Here, we measured antigenic diversity among variants and interpreted neutralizing antibody responses following single and multiple exposures in longitudinal infection and vaccine cohorts. Antigenic cartography using primary infection antisera showed that BA.2, BA.4/BA.5, and BA.2.12.1 are distinct from BA.1 and closer to the Beta cluster. Three doses of an mRNA COVID-19 vaccine increased breadth to BA.1 more than to BA.4/BA.5 or BA.2.12.1. Omicron BA.1 post-vaccination infection elicited antibody landscapes characterized by broader immunity across antigenic space than three doses alone, although with less breadth than expected to BA.2.12.1 and BA.4/BA.5. Those with Omicron BA.1 infection after two or three vaccinations had similar neutralizing titer magnitude and antigenic breadth. Accounting for antigenic differences among variants of concern when interpreting neutralizing antibody titers aids understanding of complex patterns in humoral immunity and informs selection of future COVID-19 vaccine strains.Competing Interest StatementThe authors have declared no competing interest.