RT Journal Article SR Electronic T1 OpenCap: 3D human movement dynamics from smartphone videos JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.07.07.499061 DO 10.1101/2022.07.07.499061 A1 Uhlrich, Scott D. A1 Falisse, Antoine A1 Kidziński, Łukasz A1 Muccini, Julie A1 Ko, Michael A1 Chaudhari, Akshay S. A1 Hicks, Jennifer L. A1 Delp, Scott L. YR 2022 UL http://biorxiv.org/content/early/2022/07/10/2022.07.07.499061.abstract AB Measures of human movement dynamics can predict outcomes like injury risk or musculoskeletal disease progression. However, these measures are rarely quantified in clinical practice due to the prohibitive cost, time, and expertise required. Here we present and validate OpenCap, an open-source platform for computing movement dynamics using videos captured from smartphones. OpenCap’s web application enables users to collect synchronous videos and visualize movement data that is automatically processed in the cloud, thereby eliminating the need for specialized hardware, software, and expertise. We show that OpenCap accurately predicts dynamic measures, like muscle activations, joint loads, and joint moments, which can be used to screen for disease risk, evaluate intervention efficacy, assess between-group movement differences, and inform rehabilitation decisions. Additionally, we demonstrate OpenCap’s practical utility through a 100-subject field study, where a clinician using OpenCap estimated movement dynamics 25 times faster than a laboratory-based approach at less than 1% of the cost. By democratizing access to human movement analysis, OpenCap can accelerate the incorporation of biomechanical metrics into large-scale research studies, clinical trials, and clinical practice.Competing Interest StatementStanford University has filed for a patent related to the work, titled "OpenCap: open-source software for estimating the kinematics and kinetics of human movement from smartphone videos" on behalf of A.F., S.D.U., Ł.K., J.L.H, and S.L.D. These authors have no other competing interests. J.M., M.K., and A.S.C. have no competing interests.