PT  - JOURNAL ARTICLE
AU  - Zhong-Min Ma
AU  - Katherine J. Olstad
AU  - Koen K A Van Rompay
AU  - Smita S. Iyer
AU  - Christopher J. Miller
AU  - Rachel J Reader
TI  - Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques
AID  - 10.1101/2022.07.12.499813
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.07.12.499813
4099  - http://biorxiv.org/content/early/2022/07/13/2022.07.12.499813.short
4100  - http://biorxiv.org/content/early/2022/07/13/2022.07.12.499813.full
AB  - Pulmonary immunity against SARS-CoV-2 infection has not been well studied. This study investigated the distribution of immune cells int the lungs of 8 rhesus macaques experimentally infected with SARS-CoV-2, and euthanized 11-14 days later. Using immunohistochemistry, inducible bronchus-associated lymphoid tissue was found in all animals. The inducible bronchus-associated lymphoid tissues were composed of B cells, T cells, and follicular dendritic cells with evidence of lymphocyte priming and differentiation. This suggests local immunity plays an important role in the SARS-CoV-2 infection. Further study of local immunity in the lung would benefit our understanding of SARS-CoV-2 pathogenesis and could lead to new interventions to control the SARS-CoV-2 infection and disease.Competing Interest StatementThe authors have declared no competing interest.