RT Journal Article SR Electronic T1 Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program JF bioRxiv FD Cold Spring Harbor Laboratory SP 2021.08.12.454141 DO 10.1101/2021.08.12.454141 A1 Georgios I. Laliotis A1 Evangelia Chavdoul A1 Vollter Anastas A1 Satishkumar Singh A1 Adam D. Kenney A1 Samir Acharya A1 Jacob S. Yount A1 Lalit Sehgal A1 Philip N. Tsichlis YR 2022 UL http://biorxiv.org/content/early/2022/08/04/2021.08.12.454141.abstract AB The authors have withdrawn their manuscript. While attempting to reproduce the data on the alternative splicing of exon 2 of U2AF2, they observed that the proposed splicing mechanism could not give rise to a functional U2AF2 protein. In addition, they observed evidence of manipulation in the electropherogram of the splicing junction between exons 1 and 3 and in the primary data on which this electropherogram was based, which were deposited in Mendeley by the first author. These observations raise questions on the integrity of the reported results. In light of this information, the authors have no confidence in the key findings of the paper, and therefore, do not wish it to be cited. If you have any questions, please contact the corresponding author.Competing Interest StatementThe authors have declared no competing interest.