RT Journal Article
SR Electronic
T1 Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.08.09.503303
DO 10.1101/2022.08.09.503303
A1 Márton Rózsa
A1 Martin Tóth
A1 Gáspár Oláh
A1 Judith Baka
A1 Rajmund Lákovics
A1 Pál Barzó
A1 Gábor Tamás
YR 2022
UL http://biorxiv.org/content/early/2022/08/10/2022.08.09.503303.abstract
AB Neural population activity determines the timing of synaptic inputs, which arrive to dendrites, cell bodies and axon initial segments (AISs) of cortical neurons. Action potential initiation in the AIS (AIS-APs) is driven by input integration, and the phase preference of AIS-APs during network oscillations is characteristic to cell classes. Distal regions of cortical axons do not receive synaptic inputs, yet experimental induction protocols can trigger retroaxonal action potentials (RA-APs) in axons distal from the soma. We report spontaneously occurring RAAPs in human and rodent cortical interneurons that appear uncorrelated to inputs and population activity. Network linked triggering of AIS-APs versus input independent timing of RA-APs of the same interneurons result in disparate temporal contribution of a single cell to in vivo network operation through perisomatic and distal axonal firing.One-Sentence Summary Network linked triggering of AIS-APs versus input independent timing of RA-APs of the same interneurons result in disparate temporal contribution of a single cell to in vivo network operation.Competing Interest StatementThe authors have declared no competing interest.