TY - JOUR T1 - Robustness increases heritability: implications for familial disease JF - bioRxiv DO - 10.1101/2022.08.18.504431 SP - 2022.08.18.504431 AU - Steven A. Frank Y1 - 2022/01/01 UR - http://biorxiv.org/content/early/2022/08/18/2022.08.18.504431.abstract N2 - Robustness protects organisms in two ways. Homeostatic buffering lowers the variation of traits caused by internal or external perturbations. Tolerance reduces the consequences of bad situations, such as extreme phenotypes or infections. This article shows that both types of robustness increase the heritability of protected traits. Additionally, robustness strongly increases the heritability of disease. Perhaps the natural tendency for organisms to protect robustly against perturbations partly explains the high heritability that occurs for some diseases.Competing Interest StatementThe authors have declared no competing interest. ER -