RT Journal Article
SR Electronic
T1 Is evolutionary conservation a useful predictor for cancer long noncoding RNAs? Insights from the Cancer lncRNA Census 3
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.01.506261
DO 10.1101/2022.09.01.506261
A1 Vancura, Adrienne
A1 Gutierrez, Alejandro H.
A1 Hennig, Thorben
A1 Pulido-Quetglas, Carlos
A1 Slack, Frank
A1 Johnson, Rory
A1 Häfliger, Simon
YR 2022
UL http://biorxiv.org/content/early/2022/09/04/2022.09.01.506261.abstract
AB Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census, we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for prioritisation of cancer-related lncRNAs.Competing Interest StatementThe authors have declared no competing interest.