PT  - JOURNAL ARTICLE
AU  - Quintanilla, Samantha Y.
AU  - Arejan, Neda Habibi
AU  - Patel, Parthvi B.
AU  - Boutte, Cara C.
TI  - PlrA (MSMEG_5223) is an essential polar growth regulator in <em>Mycobacterium smegmatis</em>
AID  - 10.1101/2022.09.08.507195
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.09.08.507195
4099  - http://biorxiv.org/content/early/2022/09/08/2022.09.08.507195.short
4100  - http://biorxiv.org/content/early/2022/09/08/2022.09.08.507195.full
AB  - Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new factor, PlrA, involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We show that PlrA localizes to the pole tips, and we identify its essential domain. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating polar peptidoglycan metabolism and the structure of the Wag31 polar foci.Competing Interest StatementThe authors have declared no competing interest.