RT Journal Article
SR Electronic
T1 PlrA (MSMEG_5223) is an essential polar growth regulator in <em>Mycobacterium smegmatis</em>
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.08.507195
DO 10.1101/2022.09.08.507195
A1 Quintanilla, Samantha Y.
A1 Arejan, Neda Habibi
A1 Patel, Parthvi B.
A1 Boutte, Cara C.
YR 2022
UL http://biorxiv.org/content/early/2022/09/08/2022.09.08.507195.abstract
AB Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new factor, PlrA, involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We show that PlrA localizes to the pole tips, and we identify its essential domain. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating polar peptidoglycan metabolism and the structure of the Wag31 polar foci.Competing Interest StatementThe authors have declared no competing interest.