PT - JOURNAL ARTICLE AU - Seth A. Ament AU - Ricky S. Adkins AU - Robert Carter AU - Elena Chrysostomou AU - Carlo Colantuoni AU - Jonathan Crabtree AU - Heather H. Creasy AU - Kylee Degatano AU - Victor Felix AU - Peter Gandt AU - Gwenn A. Garden AU - Michelle Giglio AU - Brian R. Herb AU - Farzaneh Khajouei AU - Elizabeth Kiernan AU - Carrie McCracken AU - Kennedy McDaniel AU - Suvarna Nadendla AU - Lance Nickel AU - Dustin Olley AU - Joshua Orvis AU - Joseph P. Receveur AU - Mike Schor AU - Timothy L. Tickle AU - Jessica Way AU - Ronna Hertzano AU - Anup A. Mahurkar AU - Owen R White TI - The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain AID - 10.1101/2022.09.08.505285 DP - 2022 Jan 01 TA - bioRxiv PG - 2022.09.08.505285 4099 - http://biorxiv.org/content/early/2022/09/09/2022.09.08.505285.short 4100 - http://biorxiv.org/content/early/2022/09/09/2022.09.08.505285.full AB - Scalable technologies to sequence the transcriptomes and epigenomes of single cells are transforming our understanding of cell types and cell states. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Cell Census Network (BICCN) is applying these technologies at unprecedented scale to map the cell types in the mammalian brain. In an effort to increase data FAIRness (Findable, Accessible, Interoperable, Reusable), the NIH has established repositories to make data generated by the BICCN and related BRAIN Initiative projects accessible to the broader research community. Here, we describe the Neuroscience Multi-Omic Archive (NeMO Archive; nemoarchive.org), which serves as the primary repository for genomics data from the BRAIN Initiative. Working closely with other BRAIN Initiative researchers, we have organized these data into a continually expanding, curated repository, which contains transcriptomic and epigenomic data from over 50 million brain cells, including single-cell genomic data from all of the major regions of the adult and prenatal human and mouse brains, as well as substantial single-cell genomic data from non-human primates. We make available several tools for accessing these data, including a searchable web portal, a cloud-computing interface for large-scale data processing (implemented on Terra, terra.bio), and a visualization and analysis platform, NeMO Analytics (nemoanalytics.org).KEY POINTSThe Neuroscience Multi-Omic Archive serves as the genomics data repository for the BRAIN Initiative.Genomic data from >50 million cells span all the major regions of the brains of humans and mice.We provide a searchable web portal, a cloud-computing interface, and a data visualization platform.Competing Interest StatementThe authors have declared no competing interest.