RT Journal Article
SR Electronic
T1 Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.07.506967
DO 10.1101/2022.09.07.506967
A1 Eleonora Piersanti
A1 Marie E. Rognes
A1 Vegard Vinje
YR 2022
UL http://biorxiv.org/content/early/2022/09/09/2022.09.07.506967.abstract
AB The intracranial pressure is implicated in many homeostatic processes in the brain and is a fundamental parameter in several diseases such as e.g. idiopathic normal pressure hydrocephalus (iNPH). The presence of a small but persistent pulsatile intracranial pulsatile transmantle pressure gradient (on the order of a few mmHg/m at peak) has recently been demonstrated in iNPH subjects. A key question is whether pulsatile ICP and displacements can be induced by a small pressure gradient originating from the brain surface e.g. pial arteries alone. In this study, we model the brain parenchyma as either a linearly elastic or a poroelastic medium and impose a pulsatile pressure gradient acting between the ventricular and the pial surfaces. Using this high-resolution physics-based model, we compute the effect of the pulsatile pressure gradient on parenchyma displacement, volume change, fluid pressure, and fluid flux. The resulting displacement field is pulsatile and in qualitatively and quantitatively good agreement with the literature, both with elastic and poroelastic models. However, the pulsatile forces on the boundaries are not sufficient for pressure pulse propagation through the brain parenchyma. Our results suggest that pressure differences originating over the brain surface via e.g. pial artery pulsatility are not sufficient to drive interstitial fluid (ISF) flow within the brain parenchyma and that potential pressure gradients found within the parenchyma rather arise from local pressure pulsations of blood vessels within the brain parenchyma itself.Competing Interest StatementThe authors have declared no competing interest.