RT Journal Article
SR Electronic
T1 PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.12.507681
DO 10.1101/2022.09.12.507681
A1 Daniel Bergman
A1 Lauren Marazzi
A1 Mukti Chowkwale
A1 Deepa Maheshvare M
A1 Supriya Bidanta
A1 Tarunendu Mapder
A1 Jialun Li
YR 2022
UL http://biorxiv.org/content/early/2022/09/15/2022.09.12.507681.abstract
AB Pharmacokinetics and pharmacodynamics are key considerations in any study of molecular therapies. It is thus imperative to factor their effects in to any in silico model of biological tissue involving such therapies. Furthermore, creation of a standardized and flexible framework will benefit the community by increasing access to such modules and enhancing their communicability. PhysiCell is an open source physics-based cell simulator, i.e. a platform for modeling biological tissue, that is quickly being adopted and utilized by the mathematical biology community. We present here PhysiPKPD, an open source PhysiCell-based package that allows users to include PKPD in PhysiCell models.Availability & Implementation The source code for PhysiPKPD is located here: https://github.com/drbergman/PhysiPKPD.Competing Interest StatementTM is an employee of Bristol-Myers Squibb.ABMagent-based modelMOAmechanism-of-actionPDpharmacodynamicsPKpharamcokinetics