PT  - JOURNAL ARTICLE
AU  - Lalwani, Poortata
AU  - Polk, Thad A.
AU  - Garrett, Douglas D.
TI  - Modulation of neural variability: Age-related reduction, GABAergic basis, and behavioral implications
AID  - 10.1101/2022.09.14.507785
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.09.14.507785
4099  - http://biorxiv.org/content/early/2022/09/17/2022.09.14.507785.short
4100  - http://biorxiv.org/content/early/2022/09/17/2022.09.14.507785.full
AB  - Moment-to-moment neural variability has been shown to scale positively with the complexity of stimulus input. However, the mechanisms underlying the ability to align variability to input complexity are unknown. Using a combination of computational modeling, fMRI, MR spectroscopy, and pharmacological intervention, we investigated the role of aging and GABA in neural variability during visual processing. We found that participants expressed higher variability when viewing more complex stimuli. Such variability modulation was associated with higher baseline visual GABA levels and was reduced in older adults. When pharmacologically increasing GABA activity, we found that participants with lower baseline GABA levels showed higher drug- related increase in variability modulation, consistent with an inverted-U account. Finally, higher baseline GABA and variability modulation were jointly associated with better visual-discrimination performance. These results suggest that GABA plays an important role in how humans utilize neural variability to adapt to the complexity of the visual world.Competing Interest StatementThe authors have declared no competing interest.