RT Journal Article
SR Electronic
T1 The cingulo-opercular network is composed of two distinct sub-systems
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.16.508254
DO 10.1101/2022.09.16.508254
A1 Caterina Gratton
A1 Ally Dworetsky
A1 Babatunde Adeyemo
A1 Benjamin A. Seitzman
A1 Derek M. Smith
A1 Steven E. Petersen
A1 Maital Neta
YR 2022
UL http://biorxiv.org/content/early/2022/09/18/2022.09.16.508254.abstract
AB The cingulo-opercular (CO) network and its two best studied regions – the dorsal anterior cingulate and anterior insula – have been linked to task control, but also implicated in many additional processes across cognitive, social, and emotional domains. However, most prior work investigating the CO network has used a group-average approach, which may mix signals across nearby regions that vary across individuals. Here, we reevaluate the CO network’s role in task control with both task and rest fMRI, using regions with a high probability of CO network agreement across individuals. Hierarchical clustering analyses suggest heterogeneity in the CO network’s task response properties, with one sub-system (CO1) showing consistency with prior task control characterizations while another sub-system (CO2) has weak task control responses, but preserved ties to pain and motor functions. Resting-state connectivity confirms subtle differences in the architecture of these two sub-systems. This evidence suggests that, when individual variation in network locations is addressed, the CO network includes (at least) two linked sub-systems with differential roles in task control and other cognitive/motor/interoceptive responses, which may help explain varied accounts of its functions. We propose that this fractionation may reflect expansion of primary CO body-oriented control functions to broader domain-general contexts.Competing Interest StatementThe authors have declared no competing interest.