PT  - JOURNAL ARTICLE
AU  - Zhao, Jingjing
AU  - Zhao, Yueye
AU  - Song, Zujun
AU  - de Schotten, Michel Thiebaut
AU  - Altarelli, Irene
AU  - Ramus, Franck
TI  - Adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia
AID  - 10.1101/2022.09.16.508343
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.09.16.508343
4099  - http://biorxiv.org/content/early/2022/09/18/2022.09.16.508343.short
4100  - http://biorxiv.org/content/early/2022/09/18/2022.09.16.508343.full
AB  - Previous studies have reported anomalies in the arcuate fasciculus (AF) lateralization in developmental dyslexia (DD). Still, the relationship between AF lateralization and literacy skills in DD remains largely unknown. The purpose of our study is to investigate the relationship between the lateralization of the AF anterior segment (AFAS), AF long segment (AFLS), and AF posterior segment (AFPS) in connection to literacy skills in DD. The participants included 26 children with dyslexia and 31 age-matched children in the control group. High angular diffusion imaging, combined with spherical deconvolution tractography, was used to reconstruct the AF. Connectivity measures of hindrance-modulated oriented anisotropy (HMOA) were computed for each of the three segments of the AF: anterior segment (AFAS), long segment (AFLS), and posterior segment (AFPS). The lateralization index (LI) of each AF segment was calculated by (right HMOA - left HMOA) / (right HMOA + left HMOA). Results showed that the LIs of AFAS and AFLS were positively correlated with reading accuracy in children with dyslexia. Specifically, the LI of AFAS was positively correlated with text and nonword reading accuracy, while the LI of AFLS accounted for word reading accuracy. The results suggest adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia and functional dissociation of the anterior segment and long segment in the compensation.Competing Interest StatementThe authors have declared no competing interest.