RT Journal Article
SR Electronic
T1 Adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.16.508343
DO 10.1101/2022.09.16.508343
A1 Zhao, Jingjing
A1 Zhao, Yueye
A1 Song, Zujun
A1 de Schotten, Michel Thiebaut
A1 Altarelli, Irene
A1 Ramus, Franck
YR 2022
UL http://biorxiv.org/content/early/2022/09/18/2022.09.16.508343.abstract
AB Previous studies have reported anomalies in the arcuate fasciculus (AF) lateralization in developmental dyslexia (DD). Still, the relationship between AF lateralization and literacy skills in DD remains largely unknown. The purpose of our study is to investigate the relationship between the lateralization of the AF anterior segment (AFAS), AF long segment (AFLS), and AF posterior segment (AFPS) in connection to literacy skills in DD. The participants included 26 children with dyslexia and 31 age-matched children in the control group. High angular diffusion imaging, combined with spherical deconvolution tractography, was used to reconstruct the AF. Connectivity measures of hindrance-modulated oriented anisotropy (HMOA) were computed for each of the three segments of the AF: anterior segment (AFAS), long segment (AFLS), and posterior segment (AFPS). The lateralization index (LI) of each AF segment was calculated by (right HMOA - left HMOA) / (right HMOA + left HMOA). Results showed that the LIs of AFAS and AFLS were positively correlated with reading accuracy in children with dyslexia. Specifically, the LI of AFAS was positively correlated with text and nonword reading accuracy, while the LI of AFLS accounted for word reading accuracy. The results suggest adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia and functional dissociation of the anterior segment and long segment in the compensation.Competing Interest StatementThe authors have declared no competing interest.