RT Journal Article
SR Electronic
T1 Foldseek: fast and accurate protein structure search
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.02.07.479398
DO 10.1101/2022.02.07.479398
A1 Michel van Kempen
A1 Stephanie S. Kim
A1 Charlotte Tumescheit
A1 Milot Mirdita
A1 Cameron L.M. Gilchrist
A1 Johannes Söding
A1 Martin Steinegger
YR 2022
UL http://biorxiv.org/content/early/2022/09/20/2022.02.07.479398.abstract
AB Highly accurate structure prediction methods are generating an avalanche of publicly available protein structures. Searching through these structures is becoming the main bottleneck in their analysis. Foldseek enables fast and sensitive comparisons of large structure sets. It reaches sensitivities similar to state-of-the-art structural aligners while being four to five orders of magnitude faster. Foldseek is free open-source software available at foldseek.com and as a webserver at search.foldseek.com.Competing Interest StatementThe authors have declared no competing interest.