PT - JOURNAL ARTICLE AU - Benjamin Rees AU - Eleonora Borda AU - Miguel A. L. Nicolelis AU - Amol P. Yadav TI - Closed-loop spinal cord stimulation is superior in restoring locomotion in rodent models of Parkinson’s Disease AID - 10.1101/2022.09.19.508432 DP - 2022 Jan 01 TA - bioRxiv PG - 2022.09.19.508432 4099 - http://biorxiv.org/content/early/2022/09/21/2022.09.19.508432.short 4100 - http://biorxiv.org/content/early/2022/09/21/2022.09.19.508432.full AB - Dorsal column stimulation (DCS) of the spinal cord is emerging as a promising new technology for the treatment of Parkinson’s disease (PD). However, the mechanisms underlying its therapeutic effect on PD symptoms are not fully understood. Here we demonstrate a closed-loop DCS (CLDCS) paradigm – a substantial advancement from previously tested continuous high-frequency DCS – in a bilateral intrastriatal 6-hydroxydopamine (6-ohda) rodent model of PD. Firstly, CLDCS performed significantly better than continuous open-loop DCS in ameliorating motor symptoms of PD. Secondly, the application of CLDCS triggered by corticostriatal beta frequency oscillations created a pro-locomotion brain state that reduced akinesia. Finally, CLDCS was better at disrupting beta oscillations in the corticostriatal areas and achieved it with lesser overall charge delivery than continuous open-loop stimulation. These results indicate that CLDCS is remarkably better than traditional spinal cord stimulation methods and has the potential to be highly effective in treating PD symptoms. We envision that the CLDCS approach can be beneficial in the treatment of other neurological disorders which showcase similar pathological neuronal oscillations.Competing Interest StatementThe authors have declared no competing interest.