RT Journal Article
SR Electronic
T1 Closed-loop spinal cord stimulation is superior in restoring locomotion in rodent models of Parkinson’s Disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.09.19.508432
DO 10.1101/2022.09.19.508432
A1 Benjamin Rees
A1 Eleonora Borda
A1 Miguel A. L. Nicolelis
A1 Amol P. Yadav
YR 2022
UL http://biorxiv.org/content/early/2022/09/21/2022.09.19.508432.abstract
AB Dorsal column stimulation (DCS) of the spinal cord is emerging as a promising new technology for the treatment of Parkinson’s disease (PD). However, the mechanisms underlying its therapeutic effect on PD symptoms are not fully understood. Here we demonstrate a closed-loop DCS (CLDCS) paradigm – a substantial advancement from previously tested continuous high-frequency DCS – in a bilateral intrastriatal 6-hydroxydopamine (6-ohda) rodent model of PD. Firstly, CLDCS performed significantly better than continuous open-loop DCS in ameliorating motor symptoms of PD. Secondly, the application of CLDCS triggered by corticostriatal beta frequency oscillations created a pro-locomotion brain state that reduced akinesia. Finally, CLDCS was better at disrupting beta oscillations in the corticostriatal areas and achieved it with lesser overall charge delivery than continuous open-loop stimulation. These results indicate that CLDCS is remarkably better than traditional spinal cord stimulation methods and has the potential to be highly effective in treating PD symptoms. We envision that the CLDCS approach can be beneficial in the treatment of other neurological disorders which showcase similar pathological neuronal oscillations.Competing Interest StatementThe authors have declared no competing interest.