PT  - JOURNAL ARTICLE
AU  - Em P Harrington
AU  - Riley B Catenacci
AU  - Matthew D Smith
AU  - Dongeun Heo
AU  - Cecilia E Miller
AU  - Keya R Meyers
AU  - Jenna Glatzer
AU  - Dwight E Bergles
AU  - Peter A Calabresi
TI  - MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
AID  - 10.1101/2022.09.27.509669
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.09.27.509669
4099  - http://biorxiv.org/content/early/2022/09/28/2022.09.27.509669.short
4100  - http://biorxiv.org/content/early/2022/09/28/2022.09.27.509669.full
AB  - Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury and disease.Competing Interest StatementThe authors have declared no competing interest.