RT Journal Article
SR Electronic
T1 Extracellular Caspase-1 regulates hair follicle stem cell migration during wound-healing
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 548529
DO 10.1101/548529
A1 Subhasri Ghosh
A1 Akshay Hegde
A1 Akhil SHP Ananthan
A1 Sunny Kataria
A1 Neha Pincha
A1 Anupam Dutta
A1 Abhik Dutta
A1 Srilekha Athreya
A1 Sneha Khedkar
A1 Rakesh Dey
A1 Aishwarya Bhosale
A1 Colin Jamora
YR 2022
UL http://biorxiv.org/content/early/2022/09/30/548529.abstract
AB The wound-healing process is a paradigm of the directed migration of various pools of stem cells from their niche to the site of injury where they replenish damaged cells. Two decades have elapsed since the observation that wounding activates multipotent hair follicle stem cells to infiltrate the epidermis, but the cues that coax these cells out of their niche remains unknown. Using an excisional wound and genetic mouse models of wound healing, we discovered that Caspase-1, a protein classically known as an integral component of the cytosolic inflammasome, is secreted and has a non-canonical role in the extracellular milieu. Through its Caspase Activation Recruitment Domain (CARD), Caspase-1 is sufficient to initiate chemotaxis of hair follicle stem cells into the epidermis. Uncovering this novel function of Caspase-1 also facilitates a deeper understanding of the mechanistic basis of the epithelial hyperplasia found to accompany numerous inflammatory skin diseases.Competing Interest StatementThe authors have declared no competing interest.