TY - JOUR T1 - Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway JF - bioRxiv DO - 10.1101/097790 SP - 097790 AU - Qian Lin AU - Suresh Jesuthasan Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/01/03/097790.abstract N2 - Light has the ability to disrupt or mask behavior that is normally controlled by the circadian clock. In mammals, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether masking is wavelength-dependent in other vertebrates, nor is it clear what higher circuits are involved. Here, we address these questions in zebrafish. We find that diel vertical migration, a circadian behavior in larval zebrafish, is effectively masked by blue, but not by red light. Two-photon calcium imaging reveals that a retino-recipient thalamic nucleus and a downstream structure, the habenula, are tuned to blue light. Lesioning the habenula inhibits light-evoked climbing. These data suggest that a thalamo-habenula pathway may be involved in the ability of blue light to mask circadian behavior. ER -