RT Journal Article
SR Electronic
T1 Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 010751
DO 10.1101/010751
A1 Martin Vinck
A1 Renata Batista-Brito
A1 Ulf Knoblich
A1 Jessica A. Cardin
YR 2014
UL http://biorxiv.org/content/early/2014/10/30/010751.abstract
AB Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a change in arousal levels. We recorded single cells and local field potentials from area V1 in mice head-fixed on a running wheel and monitored pupil diameter to assay arousal. Using naturally occurring and induced state transitions, we dissociated arousal and locomotion effects in V1. Arousal suppressed spontaneous firing and strongly altered the temporal patterning of population activity. Moreover, heightened arousal increased the signal-to-noise ratio of visual responses and reduced noise correlations. In contrast, increased firing in anticipation of and during movement was attributable to locomotion effects. Our findings suggest complementary roles of arousal and locomotion in promoting functional flexibility in cortical circuits.LFPLocal Field PotentialV1primary visual cortexPDpupil diameterFSfast spikingRSregular spikingFRfiring rateL-onlocomotion onsetL-offlocomotion offsetLlocomotionLEearly locomotionLLlate locomotionQquiescenceQEearly quiescenceQMmiddle quiescenceQLlate quiescenceSNRsignal-to-noise ratioITIInter-trial-intervalLVlocal coefficient of variationISIinter-spike-intervals.e.m.standard error of the meanSDstandard deviationIDIsolation Distance