PT  - JOURNAL ARTICLE
AU  - Arielle S. Keller
AU  - Adam R. Pines
AU  - Valerie J. Sydnor
AU  - Zaixu Cui
AU  - Maxwell A. Bertolero
AU  - Ran Barzilay
AU  - Aaron F. Alexander-Bloch
AU  - Nora Byington
AU  - Andrew Chen
AU  - Gregory M. Conan
AU  - Christos Davatazikos
AU  - Eric Feczko
AU  - Timothy J. Hendrickson
AU  - Audrey Houghton
AU  - Bart Larsen
AU  - Hongming Li
AU  - Oscar Miranda-Dominguez
AU  - David R. Roalf
AU  - Anders Perrone
AU  - Sheila Shanmugan
AU  - Russell T. Shinohara
AU  - Yong Fan
AU  - Damien A. Fair
AU  - Theodore D. Satterthwaite
TI  - Personalized Functional Brain Network Topography Predicts Individual Differences in Youth Cognition
AID  - 10.1101/2022.10.11.511823
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.10.11.511823
4099  - http://biorxiv.org/content/early/2022/10/14/2022.10.11.511823.short
4100  - http://biorxiv.org/content/early/2022/10/14/2022.10.11.511823.full
AB  - Individual differences in cognition during childhood are associated with important social, physical, and mental health outcomes in adolescence and adulthood. Given that cortical surface arealization during development reflects the brain’s functional prioritization, quantifying variation in the topography of functional brain networks across the developing cortex may provide insight regarding individual differences in cognition. We test this idea by defining personalized functional networks (PFNs) that account for interindividual heterogeneity in functional brain network topography in 9-10 year olds from the Adolescent Brain Cognitive DevelopmentSM Study. Across matched discovery (n=3,525) and replication (n=3,447) samples, the total cortical representation of fronto-parietal PFNs positively correlated with general cognition. Cross-validated ridge regressions trained on PFN topography predicted cognition across domains, with prediction accuracy increasing along the cortex’s sensorimotor-association organizational axis. These results establish that functional network topography heterogeneity is associated with individual differences in cognition before the critical transition into adolescence.Competing Interest StatementRan Barzilay reports owning stock in Taliaz Health and serving on the scientific boards of Taliaz Health and Zynerba Pharmaceuticals outside the submitted work.