PT  - JOURNAL ARTICLE
AU  - Charles Tapley Hoyt
AU  - Meghan Balk
AU  - Tiffany J. Callahan
AU  - Daniel Domingo-Fernández
AU  - Melissa A. Haendel
AU  - Harshad B. Hegde
AU  - Daniel S. Himmelstein
AU  - Klas Karis
AU  - John Kunze
AU  - Tiago Lubiana
AU  - Nicolas Matentzoglu
AU  - Julie McMurry
AU  - Sierra Moxon
AU  - Christopher J. Mungall
AU  - Adriano Rutz
AU  - Deepak R. Unni
AU  - Egon Willighagen
AU  - Donald Winston
AU  - Benjamin M. Gyori
TI  - Unifying the Identification of Biomedical Entities with the Bioregistry
AID  - 10.1101/2022.07.08.499378
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.07.08.499378
4099  - http://biorxiv.org/content/early/2022/10/22/2022.07.08.499378.short
4100  - http://biorxiv.org/content/early/2022/10/22/2022.07.08.499378.full
AB  - The standardized identification of biomedical entities is a cornerstone of interoperability, reuse, and data integration in the life sciences. Several registries have been developed to catalog resources maintaining identifiers for biomedical entities such as small molecules, proteins, cell lines, and clinical trials. However, existing registries have struggled to provide sufficient coverage and metadata standards that meet the evolving needs of modern life sciences researchers. Here, we introduce the Bioregistry, an integrative, open, community-driven metaregistry that synthesizes and substantially expands upon 23 existing registries. The Bioregistry addresses the need for a sustainable registry by leveraging public infrastructure and automation, and employing a progressive governance model centered around open code and open data to foster community contribution. The Bioregistry can be used to support the standardized annotation of data, models, ontologies, and scientific literature, thereby promoting their interoperability and reuse. The Bioregistry can be accessed through https://bioregistry.io and its source code and data are available under the MIT and CC0 Licenses at https://github.com/biopragmatics/bioregistry.Competing Interest StatementDDF received salary from Enveda Biosciences.