RT Journal Article
SR Electronic
T1 Cell-specific expression of key mitochondrial enzymes precludes OXPHOS in astrocytes of the adult human neocortex and hippocampal formation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.10.27.514048
DO 10.1101/2022.10.27.514048
A1 Arpad Dobolyi
A1 Attila G Bago
A1 Anna Stepanova
A1 Krisztina Paal
A1 Jeonghyoun Lee
A1 Miklos Palkovits
A1 Christos Chinopoulos
YR 2022
UL http://biorxiv.org/content/early/2022/10/28/2022.10.27.514048.abstract
AB The astrocyte-to-neuron lactate shuttle hypothesis entails that glycolytically derived pyruvate in astrocytes is converted to lactate instead of being catabolized in mitochondria. The mechanism of this metabolic rewiring is unclear. Here we show that astrocytes of the adult human neocortex and hippocampal formation do not express mitochondrial proteins critical for performing oxidative phosphorylation (OXPHOS) to a detectable degree, including cytochrome c and complex IV. Without OXPHOS, human brain astrocytes are bound to produce lactate to avoid interruption of glycolysis.Competing Interest StatementThe authors have declared no competing interest.