RT Journal Article
SR Electronic
T1 A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.11.04.515161
DO 10.1101/2022.11.04.515161
A1 Weiler, Simon
A1 Rahmati, Vahid
A1 Isstas, Marcel
A1 Wutke, Johann
A1 Stark, Andreas Walter
A1 Franke, Christian
A1 Geis, Christian
A1 Witte, Otto W.
A1 Hübener, Mark
A1 Bolz, Jürgen
A1 Margrie, Troy W.
A1 Holthoff, Knut
A1 Teichert, Manuel
YR 2022
UL http://biorxiv.org/content/early/2022/11/04/2022.11.04.515161.abstract
AB Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems might combine such information. Here in mice we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a subarea of primary visual cortex (VISp) whose visual space covers the whisker search space. This is mediated by local fast spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 of the primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition.Competing Interest StatementThe authors have declared no competing interest.