RT Journal Article
SR Electronic
T1 Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.11.08.515436
DO 10.1101/2022.11.08.515436
A1 Martina Milighetti
A1 Yanchun Peng
A1 Cedric Tan
A1 Michal Mark
A1 Gayathri Nageswaran
A1 Suzanne Byrne
A1 Tahel Ronel
A1 Tom Peacock
A1 Andreas Mayer
A1 Aneesh Chandran
A1 Joshua Rosenheim
A1 Matthew Whelan
A1 Xuan Yao
A1 Guihai Liu
A1 Suet Ling Felce
A1 Tao Dong
A1 Alexander J. Mentzer
A1 Julian C. Knight
A1 Francois Balloux
A1 Erez Greenstein
A1 Shlomit Reich-Zeliger
A1 Corrina Pade
A1 Joseph M. Gibbons
A1 Amanda Semper
A1 Tim Brooks
A1 Ashley Otter
A1 Daniel M Altmann
A1 Rosemary J Boyton
A1 Mala K Maini
A1 Aine McKnight
A1 Charlotte Manisty
A1 Thomas A. Treibel
A1 James C. Moon
A1 COVIDsortium Investigators
A1 Mahdad Noursadeghi
A1 Benny Chain
YR 2022
UL http://biorxiv.org/content/early/2022/11/08/2022.11.08.515436.abstract
AB We analyzed the dynamics of the earliest T cell response to SARS-COV-2. A wave of TCRs strongly but transiently expand during infection, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequences functionally annotated as SARS-COV-2 specific. Most epitopes recognized by the expanding TCRs were highly conserved between SARS-COV-2 strains, but not with circulating human coronaviruses. Many expanding CDR3s were also present at high precursor frequency in pre-pandemic TCR repertoires. A similar set of early response TCRs specific for lymphocytic choriomeningitis virus epitopes were also found at high frequency in the pre-infection naïve repertoire. High frequency naïve precursors may allow the T cell response to respond rapidly during the crucial early phases of acute viral infection.One-Sentence Summary High frequency naïve precursors underly the rapid T cell response during the crucial early phases of acute viral infection.Competing Interest StatementThe authors have declared no competing interest.