PT  - JOURNAL ARTICLE
AU  - Schweihoff, Jens F.
AU  - Hsu, Alexander I.
AU  - Schwarz, Martin K.
AU  - Yttri, Eric A.
TI  - A-SOiD, an active learning platform for expert-guided, data efficient discovery of behavior
AID  - 10.1101/2022.11.04.515138
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.11.04.515138
4099  - http://biorxiv.org/content/early/2022/11/08/2022.11.04.515138.short
4100  - http://biorxiv.org/content/early/2022/11/08/2022.11.04.515138.full
AB  - Behavior identification and quantification techniques have undergone rapid development. To this end, supervised or unsupervised methods are chosen based upon their intrinsic strengths and weaknesses (e.g. user bias, training cost, complexity, action discovery). Here, a new active learning platform, A-SOiD, blends these strengths and in doing so, overcomes several of their inherent drawbacks. A-SOiD iteratively learns user-defined groups with a fraction of the usual training data while attaining expansive classification through directed unsupervised classification. In socially-interacting mice, A-SOiD outperformed standard methods despite requiring 85% less training data. Additionally, it isolated two additional ethologically-distinct mouse interactions via unsupervised classification. Similar performance and efficiency was observed using non-human primate 3D pose data. In both cases, the transparency in A-SOiD’s cluster definitions revealed the defining features of the supervised classification through a game-theoretic approach. To facilitate use, A-SOiD comes as an intuitive, open-source interface for efficient segmentation of user-defined behaviors and discovered subactions.Competing Interest StatementThe authors have declared no competing interest.