RT Journal Article
SR Electronic
T1 A hole in Turingâ€™s theory: pattern formation on the sphere with a hole
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.11.10.515940
DO 10.1101/2022.11.10.515940
A1 Johannes G. Borgqvist
A1 Philip Gerlee
A1 Carl Lundholm
YR 2022
UL http://biorxiv.org/content/early/2022/11/11/2022.11.10.515940.abstract
AB The formation of buds on the cell membrane of budding yeast cells is thought to be driven by reactions and diffusion involving the protein Cdc42. These processes can be described by a coupled system of partial differential equations known as the Schnakenberg system. The Schnakenberg system is known to exhibit diffusion-driven pattern formation, thus providing a mechanism for bud formation. However, it is not known how the accumulation of bud scars on the cell membrane affect the ability of the Schnakenberg system to form patterns. We have approached this problem by modelling a bud scar on the cell membrane with a hole on the sphere. We have studied how the spectrum of the Laplaceâ€“Beltrami operator, which determines the resulting pattern, is affected by the size of the hole, and by numerically solving the Schnakenberg system on a sphere with a hole using the finite element method. Both theoretical predictions and numerical solutions show that pattern formation is robust to the introduction of a bud scar of considerable size, which lends credence to the hypothesis that bud formation is driven by diffusion-driven instability.Competing Interest StatementThe authors have declared no competing interest.