RT Journal Article
SR Electronic
T1 A comparative study of neuroendocrine heterogeneity in SCLC and NBL
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.11.17.516959
DO 10.1101/2022.11.17.516959
A1 Ling Cai
A1 Ralph J. DeBerardinis
A1 Yang Xie
A1 John D. Minna
A1 Guanghua Xiao
YR 2022
UL http://biorxiv.org/content/early/2022/11/18/2022.11.17.516959.abstract
AB Lineage plasticity has long been documented in both small cell lung cancer (SCLC) and neuroblastoma (NBL), two clinically distinct neuroendocrine (NE) cancers. In this study, we quantified the NE features of cancer as NE scores and performed a systematic comparison of SCLC and NBL. We found NBL and SCLC cell lines have highly similar molecular profiles and shared therapeutic sensitivity. In addition, NE heterogeneity was observed at both the inter- and intra-cell line levels. Surprisingly, we did not find a significant association between NE scores and overall survival in SCLC or NBL. We described many shared and unique NE score-associated features between SCLC and NBL, including dysregulation of Myc oncogenes, alterations in protein expression, metabolism, drug resistance, and selective gene dependencies. Our work establishes a reference for molecular changes and vulnerabilities associated with NE to non-NE transdifferentiation through mutual validation of SCLC and NBL samples.Competing Interest StatementThe authors have declared no competing interest.