PT  - JOURNAL ARTICLE
AU  - Diego Mendoza-Halliday
AU  - Alex J. Major
AU  - Noah Lee
AU  - Maxwell Lichtenfeld
AU  - Brock Carlson
AU  - Blake Mitchell
AU  - Patrick D. Meng
AU  - Yihan (Sophy) Xiong
AU  - Jacob A. Westerberg
AU  - Alexander Maier
AU  - Robert Desimone
AU  - Earl K. Miller
AU  - André M. Bastos
TI  - A ubiquitous spectrolaminar motif of local field potential power across the primate cortex
AID  - 10.1101/2022.09.30.510398
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.09.30.510398
4099  - http://biorxiv.org/content/early/2022/11/22/2022.09.30.510398.short
4100  - http://biorxiv.org/content/early/2022/11/22/2022.09.30.510398.full
AB  - The mammalian cerebral cortex is anatomically organized into a six-layer motif. It is currently unknown whether a corresponding laminar motif of neuronal activity exists across the cortex. Here, we report such a motif in the power of local field potentials (LFP). We implanted multicontact laminar probes in five macaque monkeys and recorded activity across layers in 14 cortical areas at various hierarchical processing stages in all cortical lobes. The anatomical laminar locations of recordings were histologically identified via electrolytic lesions. In all areas, we found a common spectrolaminar pattern characterized by an increasing deep-to-superficial layer gradient of gamma frequency LFP power peaking in layers 2/3, and an increasing superficial-to-deep gradient of alpha-beta power peaking in layers 5/6. Our results show an electrophysiological dissociation between superficial and deep layers that is preserved across the cortex, suggesting a ubiquitous layer and frequency-based mechanism for cortical computation.Competing Interest StatementThe authors have declared no competing interest.