RT Journal Article SR Electronic T1 A ubiquitous spectrolaminar motif of local field potential power across the primate cortex JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.09.30.510398 DO 10.1101/2022.09.30.510398 A1 Diego Mendoza-Halliday A1 Alex J. Major A1 Noah Lee A1 Maxwell Lichtenfeld A1 Brock Carlson A1 Blake Mitchell A1 Patrick D. Meng A1 Yihan (Sophy) Xiong A1 Jacob A. Westerberg A1 Alexander Maier A1 Robert Desimone A1 Earl K. Miller A1 André M. Bastos YR 2022 UL http://biorxiv.org/content/early/2022/11/22/2022.09.30.510398.abstract AB The mammalian cerebral cortex is anatomically organized into a six-layer motif. It is currently unknown whether a corresponding laminar motif of neuronal activity exists across the cortex. Here, we report such a motif in the power of local field potentials (LFP). We implanted multicontact laminar probes in five macaque monkeys and recorded activity across layers in 14 cortical areas at various hierarchical processing stages in all cortical lobes. The anatomical laminar locations of recordings were histologically identified via electrolytic lesions. In all areas, we found a common spectrolaminar pattern characterized by an increasing deep-to-superficial layer gradient of gamma frequency LFP power peaking in layers 2/3, and an increasing superficial-to-deep gradient of alpha-beta power peaking in layers 5/6. Our results show an electrophysiological dissociation between superficial and deep layers that is preserved across the cortex, suggesting a ubiquitous layer and frequency-based mechanism for cortical computation.Competing Interest StatementThe authors have declared no competing interest.