PT  - JOURNAL ARTICLE
AU  - Mingqi Zhou
AU  - Alberto Riva
AU  - Marie-Pierre L. Gauthier
AU  - Michael P. Kladde
AU  - Robert J. Ferl
AU  - Anna-Lisa Paul
TI  - Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in <em>Arabidopsis</em> roots experiencing spaceflight
AID  - 10.1101/2022.11.09.515199
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.11.09.515199
4099  - http://biorxiv.org/content/early/2022/11/23/2022.11.09.515199.short
4100  - http://biorxiv.org/content/early/2022/11/23/2022.11.09.515199.full
AB  - Flap-Enabled Next-Generation Capture (FENGC), a novel targeted DNA capture technique, has been applied to Arabidopsis root samples from the Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04) experiment onboard the International Space Station (ISS). Single-molecule long-read profiling reveals regional DNA methylation alteration that was not previously uncovered by population-based methods during spaceflight.Competing Interest StatementA patent has been submitted as an international application (No. PCT/US2022/020624, filed March 16, 2022). M.Z. and M.P.K. are two of the co-inventors of this application.