%0 Journal Article %A Zhihao Zheng %A Christopher S. Own %A Adrian A. Wanner %A Randal A. Koene %A Eric W. Hammerschmith %A William M. Silversmith %A Nico Kemnitz %A David W. Tank %A H. Sebastian Seung %T Fast imaging of millimeter-scale areas with beam deflection transmission electron microscopy %D 2022 %R 10.1101/2022.11.23.517701 %J bioRxiv %P 2022.11.23.517701 %X We have achieved a three fold increase in the speed of transmission electron microscopy by using a beam deflecting mechanism to enable highly efficient acquisition of multiple image tiles for each motion of the mechanical stage. For millimeter-scale areas, the duty cycle of imaging doubles and exceeds 30%, yielding a net average imaging rate of 0.3 gigapixels per second.Competing Interest StatementN.K. and H.S.S. disclose financial interests in Zetta AI LLC. C.S.O. and R.A.K. disclose financial interests in Voxa. A.A.W. is a founder and owner of ariadne.ai ag (Switzerland). %U https://www.biorxiv.org/content/biorxiv/early/2022/11/24/2022.11.23.517701.full.pdf