RT Journal Article SR Electronic T1 Fast imaging of millimeter-scale areas with beam deflection transmission electron microscopy JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.11.23.517701 DO 10.1101/2022.11.23.517701 A1 Zheng, Zhihao A1 Own, Christopher S. A1 Wanner, Adrian A. A1 Koene, Randal A. A1 Hammerschmith, Eric W. A1 Silversmith, William M. A1 Kemnitz, Nico A1 Tank, David W. A1 Seung, H. Sebastian YR 2022 UL http://biorxiv.org/content/early/2022/11/24/2022.11.23.517701.abstract AB We have achieved a three fold increase in the speed of transmission electron microscopy by using a beam deflecting mechanism to enable highly efficient acquisition of multiple image tiles for each motion of the mechanical stage. For millimeter-scale areas, the duty cycle of imaging doubles and exceeds 30%, yielding a net average imaging rate of 0.3 gigapixels per second.Competing Interest StatementN.K. and H.S.S. disclose financial interests in Zetta AI LLC. C.S.O. and R.A.K. disclose financial interests in Voxa. A.A.W. is a founder and owner of ariadne.ai ag (Switzerland).