RT Journal Article
SR Electronic
T1 A dopaminergic memory circuit controls acute valence
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.11.23.517775
DO 10.1101/2022.11.23.517775
A1 Mohammad, Farhan
A1 Mai, Yishan
A1 Ho, Joses
A1 Zhang, Xianyuan
A1 Ott, Stanislav
A1 Stewart, James Charles
A1 Claridge-Chang, Adam
YR 2022
UL http://biorxiv.org/content/early/2022/11/24/2022.11.23.517775.abstract
AB The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. Both immediate actions and reinforcement learning are instructed by dopamine. However, it is unknown how dopaminergic systems maintain coherence between these two reward functions. Optogenetic activation experiments showed that the dopamine neurons that inform olfactory memory in Drosophila have a distinct, parallel function driving attraction and aversion (valence). Olfactory-memory neurons were dispensable for valence. A broadly projecting set of dopaminergic cells had valence that was dependent on dopamine, glutamate, and octopamine. Similarly, a more restricted dopaminergic cluster with attractive valence was reliant on dopamine and glutamate. Opto-inhibition of this narrow subset revealed that behavior was influenced by pre-existing dopaminergic activity. Dopamine’s acute effect on valence provides a mechanism by which a dopaminergic circuit can coherently write memories to influence future responses while guiding immediate actions.Competing Interest StatementThe authors have declared no competing interest.