RT Journal Article SR Electronic T1 Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair JF bioRxiv FD Cold Spring Harbor Laboratory SP 2022.11.25.517820 DO 10.1101/2022.11.25.517820 A1 Chansoria, Parth A1 Bonacquisti, Emily A1 Heavey, Mairead A1 Le, Lina A1 Maruthamuthu, Murali Kannan A1 Blackwell, John A1 Jasiewicz, Natalie A1 Sellers, Rani S. A1 Maile, Robert A1 Wallet, Shannon A1 Egan, Thomas A1 Nguyen, Juliane YR 2022 UL http://biorxiv.org/content/early/2022/11/27/2022.11.25.517820.abstract AB Bioadhesive materials and patches are promising alternatives to surgical sutures and staples. However, many existing bioadhesives do not meet the functional requirements of current surgical procedures and interventions. Here we present a translational patch material that exhibits: (1) instant adhesion to wet tissues (2.5-fold stronger than Tisseel, an FDA-approved fibrin glue), (2) ultra-stretchability (stretching to >300% its original length without losing elasticity), (3) compatibility with rapid photo-projection (<2 min fabrication time/patch), and (4) ability to deliver therapeutics. Using our established procedures for the in silico design and optimization of anisotropic-auxetic patches, we create next generation patches for instant attachment to wet and dry tissues while conforming to a broad range of organ mechanics ex vivo and in vivo. Patches coated with exosomes demonstrate robust wound healing capability in vivo without inducing a foreign body response and without the need for patch removal that can cause pain and bleeding. We further demonstrate a new single material-based, void-filling auxetic patch designed for the treatment of lung puncture wounds.Teaser We demonstrate a sticky and highly elastic patch with conforming designs for dynamic organ repair.Competing Interest StatementThe authors have declared no competing interest.