PT  - JOURNAL ARTICLE
AU  - Parth Chansoria
AU  - Dominic Rütsche
AU  - Anny Wang
AU  - Hao Liu
AU  - Davide D’Angella
AU  - Riccardo Rizzo
AU  - Amelia Hasenauer
AU  - Patrick Weber
AU  - Nafeesah Bte Mohamed Ibrahim
AU  - Nina Korshunova
AU  - Marcy Zenobi-Wong
TI  - Synergizing algorithmic design, photoclick chemistry and multi-material volumetric printing for accelerating complex shape engineering
AID  - 10.1101/2022.11.29.518318
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.11.29.518318
4099  - http://biorxiv.org/content/early/2022/12/02/2022.11.29.518318.short
4100  - http://biorxiv.org/content/early/2022/12/02/2022.11.29.518318.full
AB  - Accelerating the designing and manufacturing of complex shapes has been a driving factor of modern industrialization. This has led to numerous advances in computational design and modeling and novel additive manufacturing (AM) techniques that can create complex shapes for bespoke applications. By combining a new coding-based design approach with high-throughput volumetric printing, we envision a new approach to transform the way we design and fabricate complex shapes. Here, we demonstrate an algorithmic voxel-based approach, which can rapidly generate and analyze porous structures, auxetic meshes and cylinders, or perfusable constructs. We use this design scheme in conjunction with new approaches for multi-material volumetric printing based on thiol-ene photoclick chemistry to rapidly fabricate complex heterogeneous structures. Collectively, the new design and fabrication technique we demonstrate can be used across a wide-spectrum of products such as actuators, biomedical implants and grafts, or tissue and disease models.Teaser A new scheme of rapidly designing and printing complex multi-material structures for implant and tissue graft applications.Competing Interest StatementCo-authors Anny Wang, Davide D'Angella and Nina Korshunova and are employed by Hyperganic Group GmbH.