RT Journal Article
SR Electronic
T1 Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 101410
DO 10.1101/101410
A1 Dejian Yuan
A1 Xiaoyun Lei
A1 Yuanyuan Gui
A1 Zuobin Zhu
A1 Dapeng Wang
A1 Jun Yu
A1 Shi Huang
YR 2017
UL http://biorxiv.org/content/early/2017/01/18/101410.abstract
AB Recent studies have established that genetic diversities are mostly maintained by selection, therefore rendering the present molecular model of human origins untenable. Using improved methods and public data, we have revisited human evolution and derived an age of 1.91-1.96 million years for the first split in modern human autosomes. We found evidence of modern Y and mtDNA originating in East Asia and dispersing via hybridization with archaic humans. Neanderthals and Denisovans were archaic Africans with Eurasian admixtures and ancestors of South Asia Negritos and Aboriginal Australians. Verifying our model, we found more ancestry of Southern Chinese from Hunan in Africans relative to other East Asian groups examined. These results suggest multiregional evolution of autosomes and East Asia origin of Y and mtDNA, thereby leading to a coherent account of modern human origins.