TY - JOUR T1 - Cognitive task information is transferred between brain regions via resting-state network topology JF - bioRxiv DO - 10.1101/101782 SP - 101782 AU - Takuya Ito AU - Kaustubh R. Kulkarni AU - Douglas H. Schultz AU - Ravi D. Mill AU - Richard H. Chen AU - Levi I. Solomyak AU - Michael W. Cole Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/01/19/101782.abstract N2 - The brain is thought to process cognitive task information in a widespread distributed manner, yet little is known about how such information is coordinated on a global scale. We built on recent advances in decoding cognitive task information and characterizing the flow of activity through large-scale brain networks to investigate region-to-region information transfer during complex cognitive tasks. We hypothesized that resting-state functional network topology – revealed via correlations among brain activity time series during task-free rest – describes the fine-grained mappings between brain regions that carry cognitive task information. Confirming this, we found that diverse task-rule information could be predicted in held-out brain regions based on estimated activity flow through resting-state network connections. Activity flow over fine-grained resting-state connections thus provides a large-scale network mechanism for cognitive task information transfer in the human brain. ER -