PT  - JOURNAL ARTICLE
AU  - Nelson Espinosa
AU  - Alejandra Alonso
AU  - Cristian Morales
AU  - Pablo Fuentealba
TI  - Basal forebrain gating by somatostatin neurons drives cortical activity
AID  - 10.1101/102582
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 102582
4099  - http://biorxiv.org/content/early/2017/01/23/102582.short
4100  - http://biorxiv.org/content/early/2017/01/23/102582.full
AB  - The basal forebrain provides modulatory input to the cortex regulating brain states and cognitive processing. Somatostatin-expressing cells constitute a local GABAergic source known to functionally inhibit the major cortically-projecting cell types. However, it remains unclear if somatostatin cells can regulate the basal forebrain’s synaptic output and thus control cortical dynamics. Here, we demonstrate in mice that somatostatin neurons regulate the corticopetal synaptic output of the basal forebrain impinging on cortical activity and behavior. Optogenetic inactivation of somatostatin neurons in vivo increased spiking of some basal forebrain cells, rapidly enhancing and desynchronizing neural activity in the prefrontal cortex, inhibiting slow rhythms and increasing gamma oscillations. Locomotor activity was specifically increased in quiescent animals, but not in active mice. Altogether, we provide physiological and behavioral evidence indicating that somatostatin cells are pivotal in gating the synaptic output of the basal forebrain, thus indirectly controlling cortical operations via both cholinergic and non-cholinergic mechanisms.