PT  - JOURNAL ARTICLE
AU  - Sibille, Jérémie
AU  - Gehr, Carolin
AU  - Kremkow, Jens
TI  - Efficient mapping of the thalamocortical monosynaptic connectivity <em>in vivo</em> by tangential insertions of high-density electrodes in cortex
AID  - 10.1101/2022.12.28.522000
DP  - 2022 Jan 01
TA  - bioRxiv
PG  - 2022.12.28.522000
4099  - http://biorxiv.org/content/early/2022/12/29/2022.12.28.522000.short
4100  - http://biorxiv.org/content/early/2022/12/29/2022.12.28.522000.full
AB  - Thalamus provides the principal input to cortex, thus understanding the mechanisms of cortical computations in behaving animals requires to characterize the thalamocortical connectivity in vivo. We show that tangential insertions of high-density electrodes into mouse cortex capture the activity of thalamocortical axons simultaneously with their synaptically connected cortical neurons. Multiple thalamic synaptic inputs to cortical neurons can be measured providing an efficient approach for mapping the thalamocortical connectivity in vivo.Competing Interest StatementThe authors have declared no competing interest.