RT Journal Article
SR Electronic
T1 Efficient mapping of the thalamocortical monosynaptic connectivity <em>in vivo</em> by tangential insertions of high-density electrodes in cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2022.12.28.522000
DO 10.1101/2022.12.28.522000
A1 Sibille, Jérémie
A1 Gehr, Carolin
A1 Kremkow, Jens
YR 2022
UL http://biorxiv.org/content/early/2022/12/29/2022.12.28.522000.abstract
AB Thalamus provides the principal input to cortex, thus understanding the mechanisms of cortical computations in behaving animals requires to characterize the thalamocortical connectivity in vivo. We show that tangential insertions of high-density electrodes into mouse cortex capture the activity of thalamocortical axons simultaneously with their synaptically connected cortical neurons. Multiple thalamic synaptic inputs to cortical neurons can be measured providing an efficient approach for mapping the thalamocortical connectivity in vivo.Competing Interest StatementThe authors have declared no competing interest.