RT Journal Article
SR Electronic
T1 A Unified Physiological Process Links Global Patterns of Functional MRI, Respiratory Activity, and Autonomic Signaling
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.01.19.524818
DO 10.1101/2023.01.19.524818
A1 Taylor Bolt
A1 Shiyu Wang
A1 Jason S. Nomi
A1 Roni Setton
A1 Benjamin P. Gold
A1 Blaise deB.Frederick
A1 R Nathan Spreng
A1 Shella D. Keilholz
A1 Lucina Q. Uddin
A1 Catie Chang
YR 2023
UL http://biorxiv.org/content/early/2023/01/20/2023.01.19.524818.abstract
AB Global signal fluctuations are a dominant source of variance in spontaneous BOLD activity. These brain-wide signals co-occur with respiratory and other physiological changes. An often-overlooked possibility is that these physiological associations with global BOLD fluctuations are components of a unified physiological process. Here we combine analysis of multi-modal physiological recordings with simultaneous EEG-fMRI data to demonstrate that global BOLD fluctuations are embedded in a physiological network spanning neural, cardiovascular, pulmonary, exocrine (sweat glands) and smooth muscle (pupil dilator) systems. We further show that these co-fluctuations can be initiated by voluntary changes in respiratory rate and depth. We propose that respiratory variability and its concomitant physiological dynamics are essential explanatory ingredients in the origin of global BOLD fluctuations.Competing Interest StatementThe authors have declared no competing interest.