RT Journal Article
SR Electronic
T1 Neurophysiological signatures of cortical micro-architecture
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.01.23.525101
DO 10.1101/2023.01.23.525101
A1 Golia Shafiei
A1 Ben D. Fulcher
A1 Bradley Voytek
A1 Theodore D. Satterthwaite
A1 Sylvain Baillet
A1 Bratislav Misic
YR 2023
UL http://biorxiv.org/content/early/2023/01/23/2023.01.23.525101.abstract
AB Systematic spatial variation in micro-architecture is observed across the cortex. These micro-architectural gradients are reflected in neural activity, which can be captured by neurophysiological time-series. How spontaneous neurophysiological dynamics are organized across the cortex and how they arise from heterogeneous cortical micro-architecture remains unknown. Here we extensively profile regional neurophysiological dynamics across the human brain by estimating over 6 800 timeseries features from the resting state magnetoencephalography (MEG) signal. We then map regional time-series profiles to a comprehensive multi-modal, multi-scale atlas of cortical micro-architecture, including microstructure, metabolism, neurotransmitter receptors, cell types and laminar differentiation. We find that the dominant axis of neurophysiological dynamics reflects characteristics of power spectrum density and linear correlation structure of the signal, emphasizing the importance of conventional features of electromagnetic dynamics while identifying additional informative features that have traditionally received less attention. Moreover, spatial variation in neurophysiological dynamics is colocalized with multiple micro-architectural features, including genomic gradients, intracortical myelin, neurotransmitter receptors and transporters, and oxygen and glucose metabolism. Collectively, this work opens new avenues for studying the anatomical basis of neural activity.Competing Interest StatementThe authors have declared no competing interest.