PT  - JOURNAL ARTICLE
AU  - Yasin F Dagdas
AU  - Pooja Pandey
AU  - Nattapong Sanguankiattichai
AU  - Yasin Tumtas
AU  - Khaoula Belhaj
AU  - Cian Duggan
AU  - Maria E Segretin
AU  - Sophien Kamoun
AU  - Tolga O Bozkurt
TI  - Host autophagosomes are diverted to a plant-pathogen interface
AID  - 10.1101/102996
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 102996
4099  - http://biorxiv.org/content/early/2017/01/30/102996.short
4100  - http://biorxiv.org/content/early/2017/01/30/102996.full
AB  - Filamentous plant pathogens and symbionts invade their host cells but remain enveloped by host-derived membranes. The mechanisms underlying the biogenesis and functions of these host-microbe interfaces are poorly understood. Recently, we showed that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host protein ATG8CL to stimulate autophagosome formation and deplete the selective autophagy receptor Joka2 from ATG8CL complexes. Here, we show that during P. infestans infection, ATG8CL autophagosomes are diverted to the pathogen interface. Our findings are consistent with the view that the pathogen coopts host selective autophagy for its own benefit.