RT Journal Article
SR Electronic
T1 Ketamine evoked disruption of entorhinal and hippocampal spatial maps
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2023.02.05.527227
DO 10.1101/2023.02.05.527227
A1 Francis Kei Masuda
A1 Yanjun Sun
A1 Emily A Aery Jones
A1 Lisa M Giocomo
YR 2023
UL http://biorxiv.org/content/early/2023/02/06/2023.02.05.527227.abstract
AB Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial cognition side effects including out-of-body experiences and spatial memory impairments. The neural substrates that underlie these alterations in spatial cognition however, remain incompletely understood. Here, we used electrophysiology and calcium imaging to examine ketamine’s impacts on the medial entorhinal cortex and hippocampus, which contain neurons that encode an animal’s spatial position, as mice navigated virtual reality and real world environments. Ketamine induced an acute disruption and long-term re-organization of entorhinal spatial representations. This acute ketamine-induced disruption reflected increased excitatory neuron firing rates and degradation of cell-pair temporal firing rate relationships. In the reciprocally connected hippocampus, the activity of neurons that encode the position of the animal was suppressed after ketamine administration. Together, these findings point to disruption in the spatial coding properties of the entorhinal-hippocampal circuit as a potential neural substrate for ketamine-induced changes in spatial cognition.Competing Interest StatementThe authors have declared no competing interest.