PT  - JOURNAL ARTICLE
AU  - Leonhard Waschke
AU  - Fabian Kamp
AU  - Evi van den Elzen
AU  - Suresh Krishna
AU  - Ulman Lindenberger
AU  - Ueli Rutishauser
AU  - Douglas D. Garrett
TI  - Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans
AID  - 10.1101/2023.02.23.529684
DP  - 2023 Jan 01
TA  - bioRxiv
PG  - 2023.02.23.529684
4099  - http://biorxiv.org/content/early/2023/02/23/2023.02.23.529684.short
4100  - http://biorxiv.org/content/early/2023/02/23/2023.02.23.529684.full
AB  - During memory formation, the hippocampus is presumed to represent the “content” of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features that comprise each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.Competing Interest StatementThe authors have declared no competing interest.